Living Organisms
Sigma Aldrich Fine Chemicals Biosciences Hirudin from leeches lyoph
Hirudin is a 7 kDa acidic protein containing 65 amino acid residues that has an isoelectric point of 3.5-4.0. It is not glycosylated and lacks tryptophan arginine and methionine residues. It is chemically stable between pH 2-12 and at temperatures up to 80C.
Cayman Chemical Harmalol hydrochloride hydra
A uPA and factor Xa inhibitor (Kis 1 8 and 8 7 UM respectively)
Cayman Chemical L-TyrosInsodIum salt hydra 50g
A methylated purine nucleoside urinary levels are increased in patients with acute myelomonocytic leukemia or large cell lung carcinoma urinary levels are increased in patients with breast cancer and are associated with a reduced five-year survival rate
Cayman Chemical LTyrosInsodIum salt hydra 100g
An AChE inhibitor induces LTP in rat hippocampal slices at 10 UM prevents scopolamine-induced memory deficits in the passive avoidance test in rats from 0 03-1 mg/kg
Cayman Chemical A943931hydrochLRIde hydra 5mg
An internal standard for the quantification of hexanoicacid by GC- or LC-MS
Cayman Chemical A943931hydroCLOrID hydra 10mg
An irreversible inhibitor of TrxR1 (IC50 0.012 UM) inhibits TrxR1-induced reduction of Trx1 in a cell-free assay (IC50 4.3 UM) reduces the mitochondrial oxygen consumption rate in HCT116 cells at 10 UM increases the intracellular levels of hydrogen peroxide in FaDu cancer cells in a time- and concentration-dependent manner decreases the viability of FaDu cells (IC50 0.72 UM) decreases tumor growth in a FaDu HNSCC mouse xenograft model at 10 mg/kg twice per day induces apoptosis in a FaDu HNSCC mouse xenograft model at 5 mg/kg daily toxic to S. mansoni adult worms (LD50 10.07 UM)
Cayman Chemical Cefotiam hydrochloride hydra
A fungal metabolite inhibits NFRD (IC50 1.7 UM in A. suum mitochondria) and NADH oxidase (IC50 3 UM in bovine heart mitochondria) active against B. subtilis K. rhizophila and M. smegmatis in disc assays
Cayman Chemical MetIxenhydrochlorIde hydra 5mg
A metabolite of adrenic acid activates KCa1.1/BK in isolated rat coronary small arterial smooth muscle cells at 50 nM induces dilation of isolated porcine arterioles (EC50 12 pM) induces relaxation of U-46619-precontracted isolated bovine coronary arteries
Cayman Chemical FungI FuscIn 10mg
A multi-kinase inhibitor inhibits human Aurora kinase B (IC50 250 nM) and the T brucei homolog Aurora kinase-1 (IC50 40 nM) inhibits AMPK LCK MKK1 MAPKAP-K1 CHK1 and PHK in a panel of 25 kinases at 1 UM inhibits MEKK2 in ATPase and transphosphorylation assays (IC50s 60 and 34 nM respectively) induces polyploidy and defects in cytokinesis and spindle assembly as well as inhibits proliferation of HeLa cells and overrides paclitaxel- and monastrol-induced mitotic arrest from 50-100 nM induces toxicity in HepG2 cells (TC50 50 0 22-2 21 UM) inhibits the growth of T brucei L major promastigotes and amasigotes and P falciparum (EC50s 0 01-2 37 UM)
Cayman Chemical MetIxenhydrochLRIde hydra 10mg
An ETB receptor agonist selectively binds to ETB over ETA receptors (IC50s 0.33 and 570 nM respectively for the porcine receptors) increases wound closure percentage in a scratch assay using HUVECs at 10 or 100 nM increases body temperature in conscious rabbits at 0.15 or 0.3 nmol/kg induces bronchoconstriction and increases mean arterial blood pressure in anesthetized guinea pigs at 20 nmol/kg i.v. has been used to determine the cross reactivity of monoclonal antibodies against endothelin in enzyme immunometric assays
Cayman Chemical PemetrexedodIum salt hydra 5mg
A PARP inhibitor (IC50 5 4 UM in C3H/10T1/2 mouse stem cells) inhibits spontaneous as well as FGF2-induced cell invasiveness of HUVECs at 50 UM induces tubulogenesis and reduces FGF2-induced expression of UPA in HUVECs at 50 UM reduces telomere length in HeLaS3 human cervical cancer cells and non-cancerous COM3 hamster cells
Cayman Chemical BIX01294hydroCLOrID hydra 10mg
A synthetic intermediate useful for pharmaceutical synthesis
Cayman Chemical Pemetrexed sodium salt hydra
A CB1 receptor inverse agonist (IC50 8 5 nM for the human receptor) selective for CB1 over CB2 receptors (IC50 604 9 nM for the human receptor) inhibits diet-induced increases in body weight epididymal and inguinal fat pad mass and serum levels of insulin and triglycerides as well as hepatic triglyceride levels in a mouse model of high-fat diet-induced obesity at 10 mg/kg per day increases the levels of Ucp1 in brown adipose tissue from as well as induces thermogenesis in mice in the same mouse model